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Maria Gloria Dominguez Bello

Maria Gloria Dominguez Bello headshot.

Laboratory Website

Lipman Hall, Room 333B
76 Lipman Drive
New Brunswick, NJ 08901-8525

Curriculum Vitae (151k PDF)

Research Interests

My research interest focuses on the microbiome development from birth, functions for the host, impact by practices that reduce microbial transmission or disrupt the microbiota, and strategies for restoration. We also study how Westernization changes environmental microbes and human exposures, integrating the fields of anthropology and architecture/urban studies into microbial ecology.

Current Projects

1. Effects of C-section on development

The major goal of this study is to determine perinatal microbial factors that protect against or predispose to metabolic diseases and to type 1 diabetes. JDRF; Emch Fund; C&D Fund, CIFAR, SEBS-IFNH-Seed grant.

2. Effect of lack of direct breastfeeding on the infant microbiome development

The major goal of this study is to determine whether bottle-feeding maternal breastmilk introduces developmental changes in the microbiome of babies. Funds: Emch Fund; C&D Fund, CIFAR.

3. The microbiome of isolated peoples

Hunter-gatherer societies bring a unique opportunity as a proximities to pre-urban life practices (void of antimicrobial factors such as antibiotics, C-sections, excessive hygiene). This project studies the community structure and function of the bacterial populations in the body of traditional peoples, to understand their protective effect against modern immune and metabolic diseases. Funds: Emch Fund; C&D Fund.

Publications List

Selected Publications, 2019–Present

  1. Fragiadakis GK, Smits SA, Sonnenburg ED, Van Treuren W, Reid G, Knight R, Manjurano A, Changalucha J, Dominguez-Bello MG, Leach J, Sonnenburg JL. Links between environment, diet, and the hunter-gatherer microbiome. Gut Microbes 2019, 10(2):216-227; DOI:10.1080/19490976.2018.1494103.
  2. PeBenito A, Nazzal L, Huan C, Li H, Jay M, Noya-Alarcon O, Contraras M, Lander O, Leach J, Dominguez-Bello MG, Blaser MJ. Comparative prevalence of Oxalobacter formigenes in three human populations. Sci Reports 2019, 9:574; DOI:10.1038/s41598-018-36670-z
  3. Pagán-Jiménez M, Ruiz-Calderón JF, Dominguez-Bello MG, García-Arrarás JE. Characterization of the intestinal microbiota of the sea cucumber Holothuria glaberrima. PLoS ONE 2019, 14(1): e0208011; DOI:10.1371/journal.pone.0208011
  4. Robello, C, Maldonado, D. P, Hevia, A, Hoashi, M, Frattaroli, P, Montacutti, V, Heguy, A, Dolgalev, I, Mojica, M, Iraola, G, Dominguez-Bello, M. G. The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole. PLoS One 2019, 14(2): e0212593; DOI: 10.1371/journal.pone.0215199
  5. Dominguez-Bello MG, Godoy-Vitorino F, Knight R, Blaser MJ. Role of the microbiome in human development. Gut 2019, Jun;68(6):1108-1114; DOI:10.1136/ gutjnl-2018-317503
  6. Murphy K, Keller MJ, Sinclair S, Devlin JC, Starkman B, Shi Q, Hoover DR, Freiermuth J, Minkoff H, Anastos K, Dominguez-Bello MG, Herold BC. Impact of reproductive aging on the vaginal microbiome and soluble immune mediators in women living with and at-risk for HIV infection. PLoS One 2019, 14 (4): e0216049; DOI 10.1371/journal.pone.0216049
  7. McCall LI, Callewaert C, Zhu Q, Song SJ, Bouslimani A, Minich JJ, Ernst M, Ruiz-Calderon JF, Cavallin H, Pereira HS, Novoselac A, HernandezJ, Rios R, Branch OH, Blaser MJ, Paulino LC, Dorrestein PC, Knight R, Dominguez-Bello MG. Home Chemical and Microbial Transitions with Urbanization. Nature Microbiology 2019, Jan;5(1):108-115; DOI:10.1038/s41564-019-0593-4
  8. Mueller N, Dominguez-Bello MG, Appel L, Hourigan S. Vaginal seeding' after a caesarean section provides benefits to newborn children." BJOG: An International Journal of Obstetrics and Gynaecology 2019 Jan;127(2):301; DOI:10.1111/1471-0528.15979
  9. Mueller NT, Hourigan SK, Hoffmann DE, Levy L, von Rosenvinge EC, Chou B, Dominguez-Bello MG. Bacterial Baptism: Scientific, Medical, and Regulatory Issues Raised by Vaginal Seeding of C-Section-Born Babies. J Law Med Ethics 2019, 47(4):568-578; DOI:10.1177/1073110519897732.
  10. Derilus D, Godoy-Vitorino F, Rosado Rivera H, Agosto E, Dominguez Bello MG, Cavallin H. An in-depth survey of the microbial landscape of the walls of a neonatal Operating Room. PLoS ONE 2020, 15(4): e0230957; DOI:10.1371/journal. pone.0230957
  11. Finlay B. B and CIFAR Humans and the Microbiome authors (Blaser MJ, Bosch TCG, Dominguez-Bello MG, Elinav E, McFall-Ngai M, Melby MK, Muehlmann SR, Sansonetti PJ. Are noncommunicable diseases communicable? Science 2020, 367 (6475): 250-251; DOI:10.1126/science.aaz3834
  12. Francis AP, Dominguez-Bello MG. Early Life Microbiota Perturbations and Behavioral Effects. Trends in Microbiology 2019 Epub 2019 Sep 28. PMID 31103277; DOI:10.1016/j.tim.2019.04.004.
  13. Lago P, Dominguez-Bello MG, Leis MR. Cesarea, Microbioma y Patologia. Cuadernos de Medicina Reproductiva 2019 (Spanish) 25(2):75-81.
  14. Derilus D, Rosado H, Agosto E, Dominguez-Bello MG, Cavallin H. An in-depth survey of the microbial landscape of the walls of a neonatal operating room. PLoS ONE 2020 April3; DOI:10.1371/journal.pone.0230957
  15. Garcia-Recinos L, Burrowes P, Dominguez-Bello M. The skin microbiota of Eleutherodactylus frogs: effects of host ecology, phylogeny, and local environment. Frontiers Microbiology 2019. 10:2571. DOI:10.3389/fmicb.2019.02571
  16. Wong W, Sabu P, Deopujari V, Levy S, Shah A, Clemency N, Provenzano M, Saadoon R, Munagala A, Baker R, Baveja R, Mueller N, Dominguez Bello MG, Huddleston K, Niederhuber J, Hourigan S. Prenatal and peripartum exposure to antibiotics and Cesarean Section delivery alters the infant meconium microbiome. Microorganisms 2020, 8(2):179. DOI:10.3390/microorganisms8020179
  17. Hernandez CD; Shin H; Troncoso PA; Vera MH; Villagran AA; Rodriguez SM; Ortiz MA; Serrano CA; Borzutzky A; Dominguez-Bello MG; Harris PR. Maternal H. pylori is associated with differential fecal microbiota in infants born by vaginal delivery. Scientific Reports 2020 10, # 7305. DOI:10.1038/s41598-020-64296-7
  18. Bisgaard H, Rasmussen M, Thorsen J, Dominguez-Bello MG, Blaser M, Mortensen M, Brejnrod, Shiraz Shah A, Hjelmso M, Lehtimäki J, Trivedi U, Sørensen S, and Stokholm J. Ecological succession in the vaginal microbiota during pregnancy and birth ISME 2020-19-00814AR2; DOI:10.1038/s41396-020-0686-3
  19. Vargas-Robles D, Magris M, Morales N, Rodríguez I, Nieves T, Godoy-Vitorino F, Alcaraz LD, Pérez ME, Ravel J, Forney LJ , Domínguez-Bello MG. Changes in the vaginal microbiota across a gradient of urbanization Scientific Reports 2020, 10:12487. DOI:10.1038/s41598-020-69111-x