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11:115:404: General Biochemistry II

(3 credits)

Offered

This is a lecture course which is offered each Spring semester. It is the second half of a one-year sequence, the first half being General Biochemistry 403, which is given in the Fall.

Prerequisites and Registration Restrictions

Pre-requisites: 01:160:307-308 Organic Chemistry or 315-316 Honors Organic Chemistry with grades of C or better. For pre-requisite overrides or special permission contact Jackie Vinasco (jacqueline.vinasco@rutgers.edu).

Format

Two 80-minute lectures per week plus self-paced self-teaching computational exercises in structural biology.

Description

A comprehensive survey of the chemistry and metabolism of biological compounds, including proteins, polysaccharides, lipids, and nucleic acids. Enzyme kinetics, bioenergetics, organelles, and cellular organization. Expression and processing of biological information, including DNA replication; transcription into RNA; translation into protein, regulation, and recombinant DNA techniques. A detailed computer laboratory study of structural biology, including protein and nucleic acid three-dimensional structures and the interactions between these and ligands.

Topics covered

In addition to the topics given above, the course examines the bases of protein, nucleic acid and membrane stability and protein folding. Energy metabolism, including photosynthesis is covered in detail. Biochemical signaling and evolutionary development of macromolecular structure and function are treated.

Course Book

Lehninger Principles of Biochemistry. David L. Nelson and Michael M. Cox. Sixth Edition W.H Freeman & Company; ISBN-13: 978-1-4292-3414-6. There is also a laboratory manual for the structural biology work which is purchased from the department.

Learning Goals

Students will gain a fundamental understanding of what makes living systems tick at the molecular level. They will also gain an understanding of the experimental methods which give rise to biochemical knowledge. The course aims to impart a thorough grasp of the relationship between biochemical structure and function.

Examinations

Three 80-minute exams (15% of the grade each) and a three-hour final (30%).

Other Requirements

The structural biology computational laboratory exercises comprise 20% of the grade, while problems sets are 5%.

Syllabus

A detailed syllabus will be available at the first class meeting and posted on the course Sakai page.

Additional Information

Contact the instructor, Prof. Peter Kahn, 120 Lipman Hall, Cook Campus. Telephone: 848-932-5618 Email: peter.kahn@rutgers.edu