Offered:
This is a lecture course which is offered each Spring semester.
Prerequisites and Registration Restrictions:
11:115:403,404 General Biochemistry I and II.
For Pre-requisite overrides or Special Permission contact the Instructor.
Format
Two 80-minute lectures per week.
Description
Course covers the role of biochemical mechanisms in cancer, including DNA damage/repair mechanisms; oncogenes/tumor suppressor genes; signaling pathways; apoptosis/cell death; the cell cycle; metastasis-cell, cell contact, and protease activation; tumor growth and angiogenesis; genetic events; genetic polymorphisms; chemical carcinogenesis; chemotherapeutic targeting. The course is a 3-credit course, with lectures and student presentations of current research in the area.
Topics Covered
DNA damage/repair mechanisms; oncogenes/tumor suppressor genes; signaling pathways; apoptosis/cell death; the cell cycle; metastasis-cell, cell contact, and protease activation; tumor growth and angiogenesis; genetic events; genetic polymorphisms; chemical carcinogenesis; chemotherapeutic targeting
Course Book
The Biology of Cancer, Weinberg (2007)
Learning Goals
Students will gain an understanding of the fundamental mechanism of cancer and cancer therapy, as well as gain experience in understanding and presenting current research in the cancer field.
Examinations
Two short essay exams.
Other Requirements
Students are expected to do one oral presentation on a recent research paper, and to write a final paper.
Syllabus
A detailed syllabus will be available at the first class meeting and posted on the course Sakai page.
Additional Information
Contact Dr. Lori A. White, Rm 128, Lipman Hall, email: lori.white@rutgers.edu.